My research interests are based principally on the study of the dynamic and structural properties of paramagnetic metal complexes with potential applications in MRI and Molecular Imaging. Particular attention is devoted to their interactions with biological macromolecular systems either in in vitro cellular and in vivo animal models. In recent years I’ve been engaged in the development of new MRI contrast agents endowed with high specificity towards particular target molecules for the detection of tumour cells as well as in the study of new probes which answer is responsive of a particular bio-parameter of interest. Presently, my main research activity concerns the study of phenomena associated with the problem of Gd retention in the body upon repeated administrations of Gd-based Contrast Agents.