Dario Longo is author of more than 70 papers in peer-reviewed journals and of 11 book chapters.
Full list of publications are available at
PubMed
, Scopus
or at Google Scholar.
Journal Papers
- Martina Capozza, Annasofia Anemone, Chetan Dhakan, Melania Della Peruta, Martina Bracesco, Sara Zullino, Daisy Villano, Enzo Terreno, Dario Livio Longo, Silvio Aime. "GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with [18F]F-FDG-PET" Molecular Imaging and Biology, 2021, in press
- Annasofia Anemone, Martina Capozza, Francesca Arena, Sara Zullino, Paola Bardini, Enzo Terreno, Dario Livio Longo, Silvio Aime. "In vitro and in vivo comparison of the MRI glucoCEST properties between native glucose and 3OMG in a murine tumor model" NMR in Biomedicine, 2021, in press
- Consolino, Lorena; Irrera, Pietro; Romdhane, Feriel; Anemone, Annasofia; Longo, Dario Livio. "Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging" Magnetic Resonance in Medicine, 2021, 86, 995
- Romdhane, Feriel; Villano, Daisy; Irrera, Pietro; Consolino, Lorena; Longo, Dario Livio. "Evaluation of a similarity anisotropic diffusion denoising approach for improving in vivo CEST-MRI tumor pH imaging" Magnetic Resonance in Medicine, 2021, 85, 3479
- Villano, Daisy; Romdhane, Feriel; Irrera, Pietro; Consolino, Lorena; Anemone, Annasofia; Zaiss, Moritz; Dastru, Walter; Longo, Dario Livio. "A Fast Multislice Sequence for 3D MRI-CEST pH Imaging" Magnetic Resonance in Medicine, 2021, 85, 1335
- Annasofia Anemone, Lorena Consolino, Laura Conti, Pietro Irrera, Myriam Hsu, Daisy Villano, Walter Dastrù, Paolo Porporato, Federica Cavallo, and Dario Livio Longo. "Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential" British Journal of Cancer, 2021, 124, 207
- Jason R. Swedlow, Pasi Kankaanpää, Ugis Sarkans, Wojtek Goscinski, Graham Galloway, Ryan P. Sullivan, Claire M. Brown, Chris Wood, Antje Keppler, Ben Loos, Sara Zullino, Dario Livio Longo, Silvio Aime, Shuichi Onami. "A Global View of Standards for Open Image Data Formats and Repositories" Nature Methods, 2021, in press
- Margherita Cortini, Andrea Armirotti, Marta Columbaro, Dario Livio Longo, Gemma Di Pompo, Elena Cannas, Alessandra Maresca, Costantino Errani, Alessandra Longhi, Alberto Righi, Valerio Carelli, Nicola Baldini, Sofia Avnet. "Exploring metabolic adaptations to the acid microenvironment of osteosarcoma unveils sphingosine 1-phosphate as a valuable therapeutic target" Cancers, 2021, 13, 311
- Martina Capozza, Rachele Stefania, Luisa Rosas, Francesca Arena, Lorena Consolino, Annasofia Anemone, James Cimino, Dario Livio Longo and Silvio Aime. "An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin" Applied Sciences 2020, 10, 8313
- Grunewald, Thomas G. P.; Alonso, Marta; Avnet, Sofia; Banito, Ana; Burdach, Stefan; Cidre-Aranaz, Florencia; Di Pompo, Gemma; Distel, Martin; Dorado-Garcia, Heathcliff; Garcia-Castro, Javier; Gonzalez-Gonzalez, Laura; Grigoriadis, Agamemnon E.; Kasan, Merve; Koelsche, Christian; Krumbholz, Manuela; Lecanda, Fernando; Lemma, Silvia; Longo, Dario Livio; Madrigal-Esquivel, Claudia; Morales-Molina, Alvaro; Musa, Julian; Ohmura, Shunya; Ory, Benjamin; Pereira-Silva, Miguel; Perut, Francesca; Rodriguez, Rene; Seeling, Carolin; Al Shaaili, Nada; Shaabani, Shabnam; Shiavone, Kristina; Sinha, Snehadri; Tomazou, Eleni M.; Trautmann, Marcel; Vela, Maria; Versleijen-Jonkers, Yvonne M. H.; Visgauss, Julia; Zalacain, Marta; Schober, Sebastian J.; Lissat, Andrej; English, William R.; Baldini, Nicola; Heymann, Dominique "Sarcoma treatment in the era of molecular medicine" EMBO Molecular Medicine, 2020, 12, e11131
- Hao Wu, Veronica Estrella, Matthew Beatty, Dominique Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, Dario Livio Longo, Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev, Kimberly Luddy, Mehdi Damaghi, Krithika Kodumudi, Smitha R. Pillai, Pedro Enriquez-Navas, Shari Pilon-Thomas, Pawel Swietach, Robert J. Gillies "T cells produce acidic niches in lymph nodes to suppress their effector functions" Nature Communications, 2020, 11, 4113
- Federica Riccardo, Giuseppina Barutello, Angela Petito, Lidia Tarone, Laura Conti, Maddalena Arigoni, Chiara Musiu, Stefania Izzo, Marco Volante, Dario Livio Longo, Irene Fiore Merighi, Mauro Papotti, Federica Cavallo, Elena Quaglino "Immunization against ROS1 by DNA electroporation impairs K-Ras-driven Lung Adenocarcinomas" Vaccines, 2020, 8, 166
- Pietro Irrera, Lorena Consolino, Juan Carlos Cutrin, Frank G. Zollner, Dario Livio Longo "Dual assessment of kidney perfusion and pH by exploiting a dynamic CEST-MRI approach in an acute kidney ischemia reperfusion injury murine model" NRM in Biomedicine, 2020, 33, e4287
- Consolino L, Anemone A, Capozza M, Carella A, Irrera P, Corrado A, Dhakan C, Bracesco M, Longo DL "Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging" Frontiers in Oncology, 2020, 10, 161
- L. Granato, DL. Longo, S. Boutry, L. Vander Elst, C. Henoumont, S. Aime, R.N. Muller, S. Laurent "Synthesis and relaxometric characterization of new Poly[N,N-bis(3AminoPropyl)Glycine] (PAPGly) dendrons Gd-based contrast agents and their in-vivo study by using the Dynamic Contrast-Enhanced MRI technique at Low field (1 T)" Chemistry & Biodiversity, 2019, 16, e1900322
- Cohen G, Hadas R, Stefania R, Pagoto A, Ben-Dor S, Kohen F, Longo DL, Elbaz M, Dekel N, Gershon E, Aime S, Neeman M "MRI reveals distinct roles for tissue transglutaminase and factor XIII in maternal angiogenesis during early mouse pregnancy" Arteriosclerosis, Thrombosis, and Vascular Biology. 2019, 39, 1602
- Anemone A, Consolino L, Arena F, Capozza M, Longo DL "Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH" Cancer Metastasis Rev. 2019, 38, 25
- Kujawa A, Kim M, Demetriou E, Anemone A, Longo DL, Zaiss M, Golay X. "Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) Imaging" Journal of Magnetic Resonance, 2019, 300, 120
- Pagoto A, Tripepi M, Stefania R, Lanzardo S, Longo DL, Garello F, Porpiglia F, Manfredi M, Aime S, Terreno E. "An efficient MRI agent targeting extracellular markers in prostate adenocarcinoma" Magnetic Resonance in Medicine 2019, 81, 1935
- Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K "Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3T, 7T and 9.4 T" NMR in Biomedicine, 2019, 32, e4113
- Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. "A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol" Magn Reson Med. 2018,79 1553
- Srivastava K, Ferrauto G, Harris S, Longo DL, Botta M, Aime S, Pierre V. "Complete On/Off Responsive ParaCEST MRI Contrast Agents for Copper and Zinc" Dalton Transactions 2018, 47, 11346
- Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P. "Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins" NMR in Biomedicine 2018, 31, e3920
- Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE. "Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting" Oxidative Medicine and Cellular Longevity 2018, 6419805
- Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL. "Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging" J Magn Reson. 2018, 287, 1
- Anemone A, Consolino L, Conti L, Reineri F, Cavallo F, Aime S, Longo DL. "In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging" Int J Oncol. 2017, 51, 498
- Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S. "Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging" Int J Pharm. 2017, 525, 275
- Longo DL, Stefania R, Aime S, Oraevsky A. "Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications" Int J Mol Sci. 2017, 18, E1719
- Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S. "Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI" NMR Biomed. 2017, 30, e3720
- Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfa I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F. "The RNA-binding protein ESRP1 promotes human colorectal cancer progression" Oncotarget. 2017, 8, 10007
- Consolino L, Longo DL, Sciortino M, Dastrù W, Cabodi S, Giovenzana GB, Aime S. "Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging" Gastric Cancer. 2017, 20, 629
- Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S. "Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy" Adv Healthc Mater. 2017, 6, 1600550
- Anemone A, Consolino L, Longo DL. "MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent" Eur Radiol. 2017, 27, 2170
- Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S. "In vivo imaging of tumour metabolism and acidosis by combining PET and MRI-CEST pH imaging" Cancer Research 2016, 76, 6463
- Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S. "Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging" Int J Cancer. 2016, 139, 404
- Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-Crich S, Giovenzana GB, Aime S. "Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1T scanners" Biomaterials. 2016 , 75, 47
- Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S. "In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents" Invest Radiol. 2016, 51, 155
- Mulas G, Anedda R, Longo DL, Roggio T, Uzzau S. "An MRI method for monitoring the ripening of Grana Padano cheese" International Dairy Journal 2016, 52, 19
- Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S. "Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment" Magn Reson Imaging. 2015, 33, 725
- Wu R, Longo DL, Aime S, Sun PZ. "Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging" NMR Biomed. 2015, 28, 555
- Voena C, Menotti M, Mastini C, Di Giacomo F, Longo DL, Castella B, Merlo MEB, Ambrogio C, Wang Q, Minero VG, Poggio T, Martinengo C, D'Amico L, Panizza E, Mologni L, Cavallo F, Altruda F, Butaney M, Capelletti M, Inghirami G, Janne PA, Chiarle R. "Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors" Cancer Immunol Res. 2015, 3, 1333
- Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E. "PI3K-C2y is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling" Nat Commun. 2015, 23, 7400
- Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbò F, Messana K, Abele C, Barreca A, Novero D, Gaudiano M, Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G; European T-cell Lymphoma Study Group. " A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation" Leukemia. 2015, 29, 1390
- Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S. "A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol" J Am Chem Soc. 2014, 136, 14333
- Perino A, Beretta M, Kili A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo DL, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. "Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive" Sci Signal. 2014, 7, ra110
- Riccardo F, Arigoni M, Buson G, Zago E, Iezzi M, Longo DL, Carrara M, Fiore A, Nuzzo S, Bicciato S, Nanni P, Landuzzi L, Cavallo F, Calogero R, Quaglino E. "Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers" BMC Genomics. 2014, 15 Suppl 3:S1
- Sun PZ, Longo DL, Hu W, Xiao G, Wu R. "Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH" Phys Med Biol. 2014, 59, 4493
- Longo DL, Di Gregorio E, Abategiovanni R, Ceccon A, Assfalg M, Molinari H, Aime S. "Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour" Analyst. 2014, 139, 2687
- Bandini S, Curcio C, Macagno M, Quaglino E, Arigoni M, Lanzardo S, Hysi A, Barutello G, Consolino L, Longo DL, Musiani P, Forni G, Iezzi M, Cavallo F. "Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice" Oncoimmunology. 2013, 2, e26137
- Avedano S, Botta M, Haigh JS, Longo DL, Woods M. "Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better" Inorg Chem. 2013, 52, 8436
- Castelli DD, Terreno E, Longo DL, Aime S. "Nanoparticle-based chemical exchange saturation transfer (CEST) agents" NMR Biomed. 2013, 26, 839
- Ceccon A, D'Onofrio M, Zanzoni S, Longo DL, Aime S, Molinari H, Assfalg M. "NMR investigation of the equilibrium partitioning of a water-soluble bile salt protein carrier to phospholipid vesicles" Proteins. 2013, 81, 1776
- Casalini F, Fugazza L, Esposito G, Cabella C, Brioschi C, Cordaro A, D'Angeli L, Bartoli A, Filannino AM, Gringeri CV, Longo DL, Muzio V, Nuti E, Orlandini E, Figlia G, Quattrini A, Tei L, Digilio G, Rossello A, Maiocchi A. "Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography" J Med Chem. 2013, 56, 2676
- Longo DL, Busato A, Lanzardo S, Antico F, Aime S. "Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent" Magn Reson Med. 2013, 70, 859
- Geninatti Crich S, Alberti D, Orio L, Stefania R, Longo DL, Aime S. "Lipid-Based Nanoparticles in Cardiovascular Molecular Imaging" Current Cardiovascular Imaging Reports 2013, 6, 69
- Arigoni M, Barutello G, Lanzardo S, Longo DL, Aime S, Curcio C, Iezzi M, Zheng Y, Barkefors I, Holmgren L, Cavallo F. "A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors" Angiogenesis. 2012, 15, 305
- Geninatti-Crich S, Szabo I, Alberti D, Longo DL, Aime S. " MRI of cells and mice at 1 and 7 Tesla with Gd-targeting agents: when the low field is better!" Contrast Media Mol Imaging. 2011, 6, 421
- Dastrù W, Longo DL, Aime S. "Contrast agents and mechanisms" Drug Discov Today Technol. 2011, 8, e109
- Longo DL, Dastrù W, Digilio G, Keupp J, Langereis S, Lanzardo S, Prestigio S, Steinbach O, Terreno E, Uggeri F, Aime S. "Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T" Magn Reson Med. 2011, 65, 202
- Botta M, Avedano S, Giovenzana GB, Lombardi A, Longo DL, Cassino C, Tei L, Aime S. "Relaxometric Study of a Series of Monoaqua GdIII Complexes of Rigidified EGTA-Like Chelators and Their Noncovalent Interaction with Human Serum Albumin" Eur J Inorg Chem 2011, 6, 802
- Tei L, Mazooz G, Shellef Y, Avni R, Vandoorne K, Barge A, Kalchenko V, Dewhirst MW, Chaabane L, Miragoli L, Longo DL, Neeman M, Aime S. "Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity" Contrast Media Mol Imaging. 2010, 5, 213
- de Leva MF, Filla A, Criscuolo C, Tessa A, Pappata S, Quarantelli M, Bilo L, Peluso S, Antenora A, Longo DL, Santorelli FM, De Michele G. "Complex phenotype in an Italian family with a novel mutation in SPG3A" J Neurol. 2010, 257, 328
- Terreno E, Dastrù W, Castelli DD, Gianolio E, Crich SG, Longo DL, Aime S. "Advances in Metal-Based Probes for MR Molecular Imaging Applications" Curr Med Chem. 2010, 17, 3684
- Terreno E, Stancanello J, Longo DL, Castelli DD, Milone L, Sanders HM, Kok MB, Uggeri F, Aime S. "Methods for an improved detection of the MRI-CEST effect" Contrast Media Mol Imaging. 2009, 4, 237
- Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF. "Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis" Exp Cell Res. 2009, 315, 285
- Baroni S, Pariani G, Fanali G, Longo DL, Ascenzi P, Aime S, Fasano M. "Thermodynamic analysis of hydration in human serum heme-albumin" Biochem Biophys Res Commun. 2009, 385, 385
- Avedano S, Tei L, Lombardi A, Giovenzana GB, Aime S, Longo DL, Botta M. "Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange" Chem Commun (Camb) 2007, 7, 4726
- Carrera C, Digilio G, Baroni S, Burgio D, Consol S, Fedeli F, Longo DL, Mortillaro A, Aime S. "Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds" J Dalton Trans 2007, 21, 4980
- Gianolio E, Giovenzana GB, Longo DL, Longo I, Menegotto I, Aime S. "Relaxometric and modelling studies of the binding of a lipophilic Gd-AAZTA complex to fatted and defatted human serum albumin" Chem Eur J 2007, 13, 5785
- Aime S, Gianolio E, Longo DL, Pagliarin R, Lovazzano C, Sisti M. "New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of Gd(III) chelates to HSA" Chembiochem. 2005, 6, 818
- Geninatti Crich S, Barge A, Battistini E, Cabella C, Coluccia S, Longo DL, Mainero V, Tarone G, Aime S. "Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates" J Biol Inorg Chem 2005, 10, 78
- Ermondi G, Caron G, Lawrence R, Longo DL. "Docking studies on NSAID/COX-2 isozyme complexes using contact statistics analysis" J Comput Aided Mol Des. 2004, 18, 683