REINERI LAB
Hyperpolarization - ParaHydrogen - Metabolism

The purpose of this research line is the development of new substrates suitable for parahydrogen hyperpolarization. Unsaturated derivatives of metabolites and of biologically relevant molecules are the main focus. The research work aims also to optimize of the parahydrogen-based hyperpolarization procedure.

The hyperpolarized metabolites (and, in particular, pyruvate) obtained by means of the PHIP-SAH method are used to investigate metabolism in different pathologies (e.g. heart failure, cancer), in cells cultures and in vivo.