Imaging Enzymatic Activity
The assessment of matrix remodelling in solid tumors is of utmost importance to stratify patients and to personalize therapy. This line of research deals with the synthesis, characterization and validation of MRI contrast agents responsive to the activity of Matrix Metalloproteinases (MMPs). Probes being developed are based on relaxation agents (for T1w-MRI) or chemical exchange saturation transfer agents (for the CEST-MRI modality) whose MRI properties change upon probe cleavage by MMPs.
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